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Simethicone is used as an ointment base, which can improve the penetration ability of the drug into the skin, improve the efficacy of the drug, improve the comfort of the patient, and increase the speed of drug dispersion. Simethicone is a high-end cream base composition that is delicate, lubricating and pearl-like, has cosmetic-like sensory intuition, and has obvious advantages in drug release speed. Below, Innovative Silicone Manufacturers introduces the common formula of simethicone;
1. Oil-in-water (O/W) cream base; active ingredient, oil phase; cetyl alcohol, simethicone, azone, stearic acid, Span-60; water phase; glycerin, purified water, etc., The proportion of simethicone is generally 6-10%. Such as ketoconazole cream and so on.
2. Water-in-oil (W/O) cream base; active ingredient, oil phase; simethicone, white petrolatum, glyceryl monostearate, Ping Ping A20, water phase; glycerin, purified water, etc., dimethyl The proportion of silicone oil is generally 1-5%. Such as compound ketoconazole cream and so on.
3. Sunscreen: 5 parts of liquid paraffin, 10 parts of white beeswax, 5 parts of microcrystalline paraffin, 5 parts of simethicone, 5 parts of white petrolatum, 1 part of polyoxyethylene sorbitan monolaurate, sorbitol 5 parts of half oleate, appropriate amount of flavor, 1 part of isopropanol myristate, 2 parts of titanium dioxide, 21 parts of purified water, and it can be obtained as a cream by the usual method. Because there are ten different models of simethicone but the same properties of products, its density and viscosity can be flexibly adjusted to a physical and chemical property. There is always a product or combination of the most suitable specifications that can adjust the best formulation product condition. This is unmatched by any other similar pharmaceutical excipients. It can be seen that simethicone, as a pharmaceutical excipient and/or active ingredient of a medicine, has excellent performance and is very safe.
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